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Computer models to predict drug clearance by liver cells show promise

A holy grail of drug discovery is to answer key questions about potential new drugs less by experiments in petri dishes and lab animals and more by faster, cheaper engineering efforts using predictive computer models.


UCSF School of Pharmacy faculty member and bioengineer Anthony Hunt, PhD, and colleagues are creating computer programs that simulate the in vitro (i.e. laboratory) interactions between drugs and cultures of hepatocytes—cells that make up most of the liver and metabolize drugs.

MoreComputer models to predict drug clearance by liver cells show promise

Tags: 
computer modeling
in silico
computer simulations
drug clearance
hepatocyte cultures
ISHCs
Key people: 
Anthony Hunt
Shahab Sheikh-Bahaei

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