Roybal, K.T., Williams, J.Z., Morsut, L., Rupp, L.J., Kolinko, I., Choe, J.H., Walker, W.J., McNally, K.A., Lim, W.A. (2016) Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 167, 419-432 See article
Summary: SynNotch T cells drive customized therapeutic responses for cancer and other diseases. SynNotch T cells can be engineered to sense tumor antigens and locally deliver biologics such as antibodies, and can thus be used as a smart platform for local delivery of diverse therapeutic payloads capable of remodeling microenvironments.
BBC Faculty to head up new NSF funded Bioengineering Center:
NSF Funds ‘Blue Sky’ Bioengineering Center To Be Based at UCSF
Center Aims to Unite Bay Area Synthetic Biologists, Engineer Biological Machines
The National Science Foundation has awarded $24 million over five years for a new ‘blue-sky’ bioengineering center based at UC San Francisco. Known as the Center for Cellular Construction, the new initiative aims to transform the field of cell biology into a quantitative discipline and to adapt tools from engineering, the physical sciences, and computer science to design automated machines out of living cells.
Researchers including faculty member Brian Shoichet develop safer opioid painkiller from scratch:
An international team of researchers — led by scientists at UC San Francisco, Stanford University, the University of North Carolina, and the Friedrich-Alexander University Erlangen-Nürnberg in Germany — has developed a new opioid drug candidate that blocks pain without triggering the dangerous side effects of current prescription painkillers. Read more:http://www.universityofcalifornia.edu/news/researchers-develop-safer-opi...